The Nurse's 3-Minute Clinical Reference is organized into four sections—Disorders, Treatments, Procedures, and Diagnostic Studies—with entries within each section organized alphabetically. Each Disorders and Procedures entry is six columns on a two-page spread; each Diagnostic Studies and Treatments entry is three columns on one page. Information is provided in brief bulleted points.

Part I covers more than 300 acute and chronic health problems including the newest conditions such as metabolic syndrome. Part II covers more than 50 treatments; Part III, more than 75 procedures; and Part IV, more than 130 diagnostic tests. Entries in each section follow a consistent format.