Product Review

Because of the overwhelming evidence connecting low levels of DHEA to problems associated with aging, Life Extension suggests that all people over age 40 begin DHEA therapy. For most people, the starting dose of DHEA is between 15-75 mg, taken in one daily dose. Many studies have used a daily dose of 50 mg. Since almost everyone over age 35-40 has lower than optimal levels of DHEA, most people begin supplementation ... and then test their blood DHEA levels later to make sure they are taking the proper dose. Normal serum reference ranges and ideal ranges of DHEA-S are: Normal (depending on age) Ideal Men 16.2-492 µg/dL 350-500 µg/dL Women 12-407 µg/dL 275-400 µg/dL People over age 40 who do not supplement with DHEA usually have serum levels below 200 µg/dL, and many are below 100 µg/dL since a steady decline takes place after the third decade in life.1,16 There are different precautions for men and women that should be observed. DHEA precautions for men Before attempting to restore DHEA to youthful levels, men should know their serum PSA (prostate specific antigen) level. Men with prostate cancer or severe benign prostate disease are advised to avoid DHEA since it can be converted into testosterone (and estrogen). Therefore, men are advised to have a PSA and digital rectal exam before initiating DHEA to rule out existing prostate disease.