Carnosine is a multifunctional dipeptide made of the amino acids beta-alanine and L-histidine. Nerve cells (neurons) and muscle cells (myocytes) contain high levels of carnosine. An anti-glycating agent, carnosine can suppre...

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Carnosine is a multifunctional dipeptide made of the amino acids beta-alanine and L-histidine. Nerve cells (neurons) and muscle cells (myocytes) contain high levels of carnosine. An anti-glycating agent, carnosine can suppress formation of advanced glycation end products (AGEs). Carnosine levels decline with age, which may account for normal age-related decline in muscle mass and function. Since carnosine acts as a pH buffer, it can protect muscle cell membranes from oxidation under acidic conditions of muscular exertion. Carnosine helps the heart muscle contract more efficiently by enhancing calcium response in heart myocytes. Glycation, seen superficially as wrinkled skin, is a cause of age-related neurologic, vascular, and eye problems. Carnosine is a unique dipeptide that can interfere with glycation.

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