Betaine, also called trimethylglycine or TMG, occurs naturally in our cells and is an excellent nutrient to improve the mood benefits of SAMe. In clinical trials, people taking betaine plus SAMe showed better mood benefits t...

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Product Review

Betaine, also called trimethylglycine or TMG, occurs naturally in our cells and is an excellent nutrient to improve the mood benefits of SAMe. In clinical trials, people taking betaine plus SAMe showed better mood benefits than others who took SAMe alone. The betaine molecule is loaded with methyl groups, which the brain needs to make and maintain DNA and overall gene and cell structure.

Betaine helps nerve cells make neurotransmitters, certain hormones, even the nerve cell electrical insulation ("myelin"). Betaine's methyl groups backup SAMe, which also occurs naturally in our cells. SAMe (S-AdenosylMethionine) is the body's main methyl transfer molecule and is required by at least 100 human enzymes that use methyl groups. In two clinical trials, people who got SAMe plus betaine experienced markedly better mood benefits than others who got SAMe alone. Our cells can further use betaine to help recycle homocysteine, a byproduct of SAMe metabolism that can become toxic if allowed to accumulate. Betaine is also used for osmotic balance, that is, to "balance" the movement of water into and out of our cells, so that they will neither shrink nor explode. Try combining Betaine TMG with BrainMD's SAMe Mood & Movement 400.

From the Manufacturer:
DOSAGE:

  • Take one capsule once or twice daily between meals.
  • To enhance SAMe for mood, we recommend taking at least one Betaine TMG capsule for each two tablets (800 mg) of SAMe that you take.
  • To promote healthy homocysteine recycling, take 2 capsules twice daily.
  • Betaine is safe to take, and some individuals may benefit from even higher intakes, as recommended by a nutritionally informed physician.
  • Keep out of reach of children. Store at room temperature in a dry place. Do not use if clear neck seal is broken or missing.


  • SAMe SUPPORT SUPPLEMENT - Betaine TMG improves the benefits of SAMe, especially when it comes to negative feelings like worry, helplessness, worthlessness, agitation, and physical efficiency.
  • SOURCE OF METHYL - Methyl is necessary to lubricate brain functions. It is also important to DNA production & repair, and brain production of melatonin and the neurotransmitters dopamine, epinephrine & norepinephrine.
  • IMPROVES BRAIN FUNCTION - Studies have seen that an increase in TMG is associated with better reaction time, memory, and brain function
  • PROTECTIVE - TMG is a key nutrient to prevent cell shrinkage or explosion. It is also beneficial to the heart and improves exercise performance & strength.
  • QUALITY & PURITY - All BrainMD products are doctor formulated and manufactured in FDA registered facilities. All of our ingredients adhere to strict purity guidelines.

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